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With any emerging technology, or combination of existing technologies, one tends to focus on the technology itself. However, the technology should not be the focal point as it in itself is not the solution. This also goes for Artificial Intelligence and the promising functionalitiesandcapabilities it can or otherwise promises to bring, enable, facilitate and augment.For instance in the vast supply chains, manufacturing, logistics, maintenance and relatedIndustry 5.0 domains. This chapter will present notions and guidance to make AI work; not just function but also to have it prepared by design with embedded non-functionals for when things may go wrong and other risks it may encounter or cause. All this for AI to help making 'it' work. This tiered approach provides value propositions that effectively address societal challenges, for which relevant AI functionalities in symbiosis with risk-based non-functionalities can be designed, deployed and continuously improved. In the Industry 5.0 domain this approach is aimed to result into valuable and feasible, human-centric, secure, safe, sustainable and otherwise trusted and trustworthy AI-supported intelligent ecosystems. With that, the symbiotic, dynamic equation of both functionals and non-functionals is one of the main successfactors for future-proof Industry 5.0 and related value creation.